![]() ![]() Our study primarily targeted glycemic control of patients with poor glycemic control with lifestyle changes and medical treatment and aimed to research the effect of blood glucose regulation on endotrophin level in patients with T2D. Additionally, the relationship between glycemic regulation and endotrophin level has not been researched. However, there is insufficient data about the endotrophin levels in patients with T2D. There are many studies investigating the correlation between adipokines with IR and T2D development. High levels of serum endotrophin found in patients with insulin resistance (IR). A variety of studies in mice and humans have associated systemic insulin resistance associated with obesity with endotrophin levels. Endotrophin is the C-terminal cleavage product, involving C5 domain of COL6α3. Collagen VI is one of the extracellular matrix (ECM) proteins secreted by adipose tissue. Īdipose tissue storing energy, it is an endocrine organ ensuring the secretion of a variety of adipokines regulating glucose and lipid metabolism. The World Health Organization (WHO) accepts both T2D and obesity as 21st century epidemic diseases. By 2045 it is expected the number of people affected by diabetes will reach 629 million. Type 2 diabetes mellitus (T2D) is a chronic degenerative metabolic disease affecting more than 425 million people in the world in general. We think that studies targeting endotrophin will contribute to the diagnosis, treatment and follow-up of diabetic nephropathy in the future. ConclusionsĮndotrophin levels decreased significantly with the decrease in HbA1c. Unexpectedly, this reduction in endotrophin levels is closely related to the decrease in UACR, regardless of blood glucose regulation. Multiple linear regression analysis showed percentage variation values (δ)-endotrophin levels were only independently correlated with (δ)-UACR (model r 2 = 0.257, p value = 0.00). The variation in serum endotrophin levels examined at the start of the study and in the 3rd month was identified to have a positive correlation with the variation in HbA1c and UACR levels (r = 0.342, p = 0.02 r = 0.484, p = 0.001). After 3 months follow-up, HbA1c, fasting glucose, C-reactive protein(CRP), UACR and endotrophin levels were observed to clearly reduce. Mean age was 55.2 years, with mean diabetes age of 8.14 ± 5.35 years. Analysis was performed using Paired-Samles T test and Spearman tests. Data of anthropometric measurements, urinary albumin creatinine ratio (UACR), serum lipid parameters and endotrophin were collected in patients all examinations were repeated after 3 months. Lifestyle changes were recommended and appropriate medical treatment was initiated to all patients in order to reach the target HbA1c level. In this prospective pilot study included 78 patients with type 2 diabete (T2D) with hemoglobin A1c level > 9 %. ![]() In this study, we aimed to investigate the effects of changes in blood glucose levels on serum endotrophin levels secreted by adipose tissue and thus on diabetes. Endotrophin is one of the extracellular matrix proteins secreted by adipose tissue. ![]()
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